There seemed to be no difference in the intensity threshold that induced language interference. None of the six patients exhibited language deficits postsurgery.
Conclusions:
Electrical cortical stimulation with modified language tasks is valid for identification of cortices underlying Mandarin processing. The great variability in language cortex distribution enhances the necessity of individual language cortical mapping in epilepsy surgery. (C) 2010 Elsevier Inc. All rights reserved.”
“Overexpression of the gene coding for alpha-synuclein has been shown to be an inherited cause of Parkinson disease. Our laboratory has previously co-expressed the parkin and Pink1 genes to rescue alpha-synuclein-induced phenotypes within a Drosophila model. To further investigate the effect of Pink1 in this model, we performed longevity Selleck LY2835219 and behavioral studies using several drivers to express the alpha-synuclein and Pink1 genes. Our findings
showed that overexpression of Pink1 and overexpression of Pink1 with alpha-synuclein PD-1/PD-L1 Inhibitor 3 mw resulted in an increased lifespan when driven with the TH-Gal4 transgene. This increase in longevity was accompanied by an increased healthspan, as measured by mobility over time, suggesting that this is an example of improved functional aging. Our results indicate that, in the dopaminergic cells targeted by TH-Gal4, increased expression of alpha-synuclein and Pink1 together have a synergistic effect, allowing for enhanced protection and increased survival of the organism.”
“Study Design. Biomechanical, in vitro, and initial in vivo evaluation of a thiol-modified hyaluronan (TM-HA) Bafilomycin A1 in vitro and elastin-like polypeptide (ELP) composite hydrogel for nucleus pulposus (NP) tissue engineering.
Objective. To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative disc disease (DDD) on the basis of both
biomechanical and biologic parameters.
Summary of Background Data. DDD is a common ailment with enormous medical, psychosocial, and economic ramifications. Only end-stage surgical therapies are currently widely available. A less invasive, early stage therapy may provide a clinically relevant treatment option.
Methods. TM-HA and ELP were combined in various concentrations and cross-linked using poly (ethylene glycol) diacrylate. Resulting materials were evaluated biomechanically using confined compression to determine biphasic material properties. In vitro cell culture with human intervertebral disc (IVD) cells seeded within TMHA/ELP scaffolds was analyzed for cell viability and phenotype. The hydrogels’ materials were evaluated in an established New Zealand White (NZW) rabbit model of DDD.
Results.