J Bacteriol 1995, 177: 4152–4156.PubMed 35. Stemke GW, Huang Y, Laigret F, Bove JM: Cloning the ribosomal RNA operons of Mycoplasma flocculare and comparison with those of Mycoplasma hyopneumoniae . Microbiology 1994, 140 (Pt 4) : 857–860.PubMedCrossRef 36. Gonzalez-y-Merchand JA, Garcia MJ, Gonzalez-Rico

S, Colston MJ, Cox RA: Strategies used by pathogenic and nonpathogenic mycobacteria to synthesize rRNA. J Bacteriol 1997, 179: 6949–6958.PubMed 37. Morozova OV, Dubytska LP, Ivanova LB, Moreno CX, Bryksin AV, Sartakova GSK2126458 ML, et al.: Genetic and physiological characterization of 23S rRNA and ftsJ mutants of Borrelia INK 128 burgdorferi isolated by mariner transposition. Gene 2005, 357: 63–72.PubMedCrossRef 38. Yang X, Popova TG, Goldberg MS, Norgard MV: Influence of cultivation media on genetic regulatory patterns in Borrelia burgdorferi . Infect

Immun 2001, 69: 4159–4163.PubMedCrossRef 39. Wang G, Iyer R, Bittker S, Cooper D, Small J, Wormser GP, et al.: Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia OSI-906 nmr burgdorferi clinical isolates. Infect Immun 2004, 72: 6702–6706.PubMedCrossRef 40. Schaechter M, Maaløe O, Kjeldgaard NO: Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimurium . J Gen Microbiol 1958, 19: 592–606.PubMed 41. Paul BJ, Berkmen MB, Gourse RL: DksA potentiates direct activation of amino acid promoters by ppGpp. Proc Natl Acad Sci USA 2005, 102: 7823–7828.PubMedCrossRef 42. Srivatsan A, Wang JD: Control of bacterial transcription, translation and replication by (p)ppGpp. Curr Opin

Microbiol 2008, 11: 100–105.PubMedCrossRef 43. Jiang M, Sullivan SM, Wout PK, Maddock JR: G-protein control of the ribosome-associated stress response protein SpoT. J Bacteriol 2007, 189: 6140–6147.PubMedCrossRef 44. Braeken K, Moris M, Daniels R, Vanderleyden J, Michiels J: New horizons for (p)ppGpp in bacterial and plant physiology. Trends Protein tyrosine phosphatase Microbiol 2006, 14: 45–54.PubMedCrossRef 45. Potrykus K, Cashel M: (p)ppGpp: still magical? Annu Rev Microbiol 2008, 62: 35–51. 35–51PubMedCrossRef 46. Sureka K, Ghosh B, Dasgupta A, Basu J, Kundu M, Bose I: Positive feedback and noise activate the stringent response regulator rel in mycobacteria. PLoS ONE 2008, 3: e1771.PubMedCrossRef 47. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72: 248–254.PubMedCrossRef 48. de Silva AM, Zeidner NS, Zhang Y, Dolan MC, Piesman J, Fikrig E: Influence of outer surface protein A antibody on Borrelia burgdorferi within feeding ticks. Infect Immun 1999, 67: 30–35.PubMed 49. Hodzic E, Feng S, Freet KJ, Barthold SW: Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice. Infect Immun 2003, 71: 5042–5055.PubMedCrossRef 50.