(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“The percentage of chemotherapy-induced necrosis in primary tumors corresponds with outcome

in several childhood malignancies, including high-risk metastatic diseases. In this retrospective pilot study, the authors assessed the importance of postchemotherapy necrosis in high-risk neuroblastoma with a histological and case notes review of surgically resected specimens. The authors reviewed all available histology of 31 high-risk neuroblastoma cases treated with COJEC (dose intensive etoposide and vincristine with either cyclophosphamide, cisplatin or carboplatin) or OPEC/OJEC (etoposide, vincristine and cyclosphosphamide with alternating

cisplatin [OPEC] or carboplatin [OJEC]) induction chemotherapy in 2 Children’s Cancer & Leukaemia Group Temsirolimus (CCLG) pediatric oncology centers. The percentage of postchemotherapy necrosis was assessed and compared with MYCN amplification status and overall survival. The median percentage of postchemotherapy tumor necrosis was 60%%. MYCN status was available for 28 cases, of which 12 were amplified (43%%). Survival in cases with >= a parts per thousand yen60%% necrosis or >= a parts per thousand yen90%% necrosis was not better than those with less necrosis, nor was percentage necrosis associated with survival using Cox regression. However, MYCN-amplified tumors showed a higher percentage of necrosis than non–MYCN-amplified

tumors, 71.3%% versus Selleckchem Alvocidib 37.2%% (P == .006). This effect was not related to prechemotherapy necrosis and did not confer improved overall survival. Postchemotherapy tumor necrosis is higher in selleck compound patients with MYCN amplification. In this study, postchemotherapy necrosis did not correlate with overall survival and should not lead to modification of postoperative treatment. However, these findings need to be confirmed in a larger prospective study of children with high-risk neuroblastoma.</.”
“High resistivity CdTe can be achieved by introducing impurities that create deep levels which, in turn, control the electronic transport properties of the material via a compensation process. We have characterized the effects of thermal annealing of high resistivity CdTe: Ge under either Te- or Cd-rich atmosphere to understand how modifications in the structure of Ge-related defective states and their electrical activity affect the material transport properties. We have investigated the transport properties with current-voltage analyses, the electrically active deep traps by photoinduced current transient spectroscopy and the local environment of Ge atoms by x-ray absorption spectroscopy.