A linear regression analysis was performed to compare the course of mean SCL between conditions in the time course T3–T4 (thereby including the interaction term between condition and time). Recall was assessed as the percentage correct recall of

provided information. To analyse the effect of click here clinician’s communication, percentage correct recall of information provided before and information provided after the start of the manipulation was calculated. T-tests were used to assess differences in recall scores between both conditions. Welch’s approximation was used in case of unequal variances. Linear regression analyses were performed to test if the variance in SCL could explain variance in percentage correct recall in both conditions, before and after T3. Participants’ mean age was 41.6 years AZD6244 in vivo (SD = 14.7; median = 44.3; range = 19–64). Other background characteristics are summarised in Table 2. No significant differences

were found between participants in the two conditions; therefore analyses were not controlled for background characteristics. Participants in the affective condition felt more reassured of medical support (?2(4,N = 50) = 12.14, p = .02) and experienced more reassurance about non-abandonment by the clinician (?2(4,N = 50) = 16.59, p = .002), as compared to the standard condition. Experienced empathy did not differ significantly between the conditions, although a trend was observed (?2(3,N = 50) = 6.80, p = .08). Participants’ mean SCL during the video-watching procedure, is shown before (Fig. 1) and after (Fig. 2) T3. Fig. 1 shows differences Decitabine ic50 in SCL between both conditions despite baseline correction and harmonisation, i.e. SCL was 0 in both conditions at the start of the video. This might be the result of substantial differences in SCL across individuals [50]. However, since we examined chances in SCL within conditions over time, this did not interfere with our analyses. Comparison of SCL on T1 (M(SD) = 1.10(0.03)) and T2 (M(SD) = 1.14(0.04)) revealed that SCL in the total sample significantly increased

when the clinician broke the bad news; t(49) = 2.99, p = .004, r2 = .15. Exploration of slopes suggests that the overall decrease in SCL before the start of the manipulation ( Fig. 1) was the same in both conditions (slope = -0.0003), but started to differ hereafter ( Fig. 2). Exploration of slopes after the start of the manipulation suggests that SCL decreased more strongly in the affective communication condition (slope = -0.0004), compared to the standard communication condition (slope = -0.0002). The linear regression model used to assess these slopes confirmed a stronger decrease in SCL over time for the affective condition, as compared to the standard condition (F(3,554) = 579.12, p < .0001). The decrease in SCL could be explained by affective communication (r2 = .77; after: r2 = .