If deemed appropriate the hepatic tear may be sutured and in some cases to achieve local haemostasis ligation of the hepatic artery is necessary. Surgical Eltanexor in vitro repair of the liver is quite different in the setting of fulminant HELLP syndrome due to the addition of impaired clotting and low platelets. Following tamponade, abdominal closure PD0332991 purchase is recommended [4]. The haematologist’s advice should be sought regarding blood transfusion, use of blood concentrates and platelets. A second look operation is performed after circa two days once haemodynamic and metabolic stabilisation has occurred. If haemostasis has not occurred repacking is the usual

surgical option with/without the administration of fibrinolysis inhibitors such as aprotinin and anti-thrombin III. Other less frequently used treatment modalities include activated factor VII [12], selective transarterial embolisation, partial liver resection, argon laser coagulation [13] and liver transplantation. Liver Transplantation This is the most recent and promising development buy LY2109761 in the management

of complicated HELLP syndrome. Orthotopic liver transplantation should be considered in the setting of uncontrollable haemorrhage, acute liver failure or macroscopic liver necrosis [14]. Of thirteen documented cases in the literature, ten made a successful recovery [6, 15]. The three deaths occurred within 7 weeks of transplantation from prolonged sepsis. With such favourable statistics, it should be a viable option when treating such high risk patients. Conclusion Although gestational hepatic rupture is a rare complication of preeclampsia, a high index of suspicion should exist when treating these patients with a focus at all times on multidisciplinary care. Although classically a condition with a mortality reaching as high as 85%, some centres boast a combined maternal – fetal mortality of 25%, reflecting the aforementioned Forskolin mw changes in the diagnosis and treatment

of this condition [16]. We contribute our favourable outcome to a multidisciplinary approach in all stages of management. Consent Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. References 1. Poo JL, Gongora J: Hepatic haematoma and hepatic rupture in pregnancy. Annals of Hepatology 2006,5(3):224–226.PubMed 2. Borekci B, Aksoy H, Toker A, Ozkan A: Placental tissue cyclo-oxygenase 1 and 2 in pre-eclamptic and normal pregnancy. Int J Gynaecol Obstet. 2006,95(2):127–131.CrossRefPubMed 3. Knopp U, Kehler U, Rickmann H, Arnold H, Gliemroth J: Cerebral haemodynamic pathologies in HELLP syndrome. Clin Neurol Neurosurg. 2003,105(4):256–261.CrossRefPubMed 4. Elsandabesee D, Hamzeh R, Pozyczka A: Hemiparesis as an unusual presentation of HELLP syndrome. J Obstet Gynaecol. 2004,24(8):926–927.CrossRefPubMed 5.