From December 2006 to April 2012, DBE was performed on 28 patients with OGIB. Results: DBE were performed in 28 patients with obscure gastrointestinal bleeding, MD were eventually detected preoperatively in 10 of them. No serious procedure-related complications were observed in any cases. All 10 children underwent laparoscopic excision of the diverticula and recovered uneventfully. Pathological examination of the excised diverticula confirmed the diagnosis of MD. Conclusion: For pediatric patients who have gastrointestinal bleeding with features highly suspicious of MD, if radioisotope scans and primary endoscopy were

negative, DBE is an efficacious and safe means of diagnosis. Key Word(s): 1. DBE; 2. MD; 3. OGIB; 4. Children; Presenting Author: CHISHINA HIROKAZU Additional Authors: TAKAYAMA MASAKI, ADACHI TEPPEI, MINE HIROMASA, NAGAI TOMOYUKI, NAGATA YOSHIAKI, KAWASAKI MASANORI, ASAKUMA YUTAKA, SAKURAI ABT-199 cell line Obeticholic Acid TOSHIHARU, MATSUI SHIGENAGA, KASHIDA HIROSHI, KUDO MASATOSHI Corresponding Author: CHISHINA HIROKAZU Affiliations: kinki university faculty of medicine; kinki university faculity of medicine; kinki university faculty of medicine; kinki university

faculty of medicine; kinki university faculty of medicine; kinki university faculty of medicine; kinki university faculty of medicine Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin are widely used for the aged patients. Recent advances in diagnostic method including SBE have enabled us to examine the entire small intestine, and we recognize that prevalence of small intestinal damage in patients taking NSAIDs is high. The aim of the present study was to analyze the clinical characteristic of small bowel diseases in the aged patients with OGIB which was

diagnosed by SBE. Methods: We investigated the clinical characteristics of the aged patients examined Selleck Ponatinib at our institute for 8 year (from July 2005 to January 2013). Small bowel mucosal injury was evaluated using SBE. Results: 96 OGIB aged patients (59 men and 37 women, mean age 70.8 years) underwent SBE from July 2005 to January 2013. Heart diseases such as ischemic heart disease, valvular diseases of the heart, atrial fibrillation were present in 36.4% and chronic renal failure in 12.5%. 40 (41.7%) patients were taking anti-thrombotics including low dose aspirin and 6 (6.3%) patients were taking NSAIDs. The most frequently detected lesions were mucosal injury which were induced by NSAIDs including low dose aspirin. Angioectasia was diagnosed in 16.7%. Among 16 patients with angioectasia, endscopic hemostasis were performed in 12 patients. The patients which small bowel diseases were detected using SBE were 41 (89.1%) in 46 patients which were taking anti-thrombotics including low dose aspirin and NSAIDs.