Conclusions In aging mice, the permeability of cochlear blood labyrinth barrier will increase in addition to level of tight junction protein will decrease; in the aging process condition, cochlear vascular stria microvascular pericytes may influence endothelial cell permeability by regulating the phrase of tight junction protein.Objective To research the treatment method and effect of surgical resection and free flap repair of recurrent malignant tumors of maxillofacial paranasal sinus and head base. Practices The clinical data of 9 patients with recurrent maxillofacial paranasal sinus and head base cancerous tumors who underwent surgical resection and free flap restoration within the division of Otorhinolaryngology Head and Neck Surgical treatment of Shandong Provincial Hospital from August 2009 to May 2019 had been Ahmed glaucoma shunt reviewed retrospectively, including 5 males and 4 females, aged 32-69 many years. There have been 4 instances of squamous cellular carcinoma, 3 cases of adenoid cystic carcinoma, 1 situation of myoepithelial carcinoma and 1 case of malignant fibrous histiocytoma. All patients had been repaired with anterolateral femoral flap. The treatment process and postoperative result were reviewed by descriptive data. Results All customers had been followed up from 16 months to 6 many years. There were 6 instances of recurrence after procedure, including 1 case of neighborhood recurrence and 5 instances of head base and craniocerebral recurrence. The median tumor free survival time of recurrent patients ended up being 35 months. Conclusion Surgical resection and no-cost flap restoration can successfully prolong the life span of customers with recurrent maxillofacial paranasal sinus and head base cancerous tumors.Objective To evaluate the effective use of area flap and combined flap in one-stage reconstruction of nasal alae defects after external nasal cyst resection. Methods Data of 11 patients with perforating or full-thickness defects associated with the alae after nasal tumor resection in XuanWu Hospital, Capital healthcare University between June 2016 and February 2021 were reviewed retrospectively. There have been 7 males and 4 females, while the centuries ranged from 51 to 89 many years. Island flap, island flap along with nasolabial flap or V-Y development flap, and area flap combined with bilobed flap were used according to the number of defects. Descriptive statistical strategy was used to evaluate the therapy impacts. Results All flaps for the 11 customers had been successful success therefore the cuts were primary healing. Becoming then followed up for 5 to 59 months, the customers had satisfying appearance and air flow purpose, and no tumor relapsed. Conclusion For the patients with nasal alae defects after exterior nostrils cyst resection, picking ideal island skin flap or combined epidermis flap can help reconstruct the ideal nasal appearance and function of the nose.Objectives to analyze the prevalence and linked risk aspects of tinnitus in Sichuan and Chongqing. Techniques We designed a tinnitus epidemiological questionnaire. The multi-stage stratified cluster arbitrary sampling practices was applied to obtain study topics in six places (Nanchong, Jiangjin, Fengdu, Yunyang, Suining and Ya’an), which were selected for epidemiological examination. Residence check out completion of epidemiological surveys ended up being carried out. The trained investigators directed the respondents to fill-in the tinnitus epidemiological questionnaires, additionally the epidemiological condition of six areas on prevalence and danger element Hepatoblastoma (HB) ended up being examined. SPSS 22.0 pc software ended up being used for statistical analysis. Results Sampling population were 10 289, by which 9 273 had been legitimate questionnaires. There have been 4 281 men and 4 992 females, with an average age 47.3 many years, among which 34.83per cent (3 230/9 273) had tinnitus. 3.99% (370/9 273) had been clinically determined to have bothersome tinnitus. In a multivariable logistic regression mod, listed here elements were connected with onsetting of tinnitus rest disorder [Odds Ratio(OR)=3.74] and noise exposure(OR=1.99). The risk of condition had been lowest into the age of 30-40 years old, while the danger of infection had been higher for people under 30 and over 40. An additional multivariable logistic regression mode, the following factors had been associated with having bothersome tinnitus seniors were almost certainly going to suffer with tinnitus, sleep problems (OR=4.68) and noise visibility (OR=1.56). Conclusions The prevalence of tinnitus in Sichuan and Chongqing is all about 34.83%, but the majority of the tinnitus is temporary and has reasonable loudness, that will maybe not affect the clients. Just only a few patients with tinnitus (3.99%) persist and influence their health and need treatment. The event and exacerbation of tinnitus can be related to sleep, age, and noise exposure.Objective To compare the medical application outcomes of the FPTF (free posterior tibial artery perforator flap) and RFFF (radial forearm free flap) for reconstruction of head and throat problems. Practices A retrospective analysis of 27 instances treated with FPTF (19 males and 8 females, elderly 14-69 years) and 24 situations with RFFF (11 men and 13 females, elderly 22-69 years) for mind and throat defect repair at Beijing Tongren Hospital of Capital Medical University from January 2015 to December 2020 was performed. Flap dimensions, vascular pedicle size, matching degree of individual location arteries, planning time, complete operation time, medical center stay, individual location complications, donor area complications BLZ945 cost and scale-based client satisfaction had been compared between two categories of patients with FTPF and RFFF. SPSS 26.0 statistical software ended up being used for analytical evaluation.