3%) compared with the single-chamber setting group (7.6%) (p = 0.001). The rates of patients with only appropriate shocks were similar in both groups (11.7% and 12.6% in the dual-chamber setting and single-chamber setting groups, respectively). Inappropriate shocks were delivered throughout the 27-month follow-up period at a rate of 7.3%, Akt inhibitor review with no clustering at any specific time point. A total of 6 patients in the dual-chamber setting group (2.6%) and 17 patients in the single-chamber setting group (7.6%) received at least 1 inappropriate shock over 12 months (p = 0.015), as did 10 patients in the dual-chamber setting

group (4.3%) and 23 patients in the single-chamber setting group (10.3%) at the end of the 27-month period (p = 0.015) (Table 3). The number of patients needed to treat to prevent 1 patient from experiencing an inappropriate shock was 17. The reasons for inappropriate shocks in the 2 treatment groups included SVTs, responsible for 73.6% of the events, and lead failure or oversensing in 25.5% of the events (Table 4). In patients in the dual-chamber setting arm, lead failure or oversensing was the major reason for inappropriate shocks (70.8%). In patients in the single-chamber Fulvestrant concentration setting arm, SVTs triggered 86.6% of all inappropriate shocks, compared with 29.2% of inappropriate

shocks in the dual-chamber setting group. A univariate analysis was performed to assess the impact of different factors (age, sex, left ventricular ejection fraction, coronary artery disease, New York Heart Association functional class, beta-blockers, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, spironolactone, class III drugs, treatment arm, implantation indication, and history of AF) on the occurrence of inappropriate shocks. Among these, only treatment arm, implantation indication, and history of AF were added in a logistic multivariate model and identified as independent predictors (dual-chamber setting vs. single-chamber setting odds ratio: 0.36; 95% CI: 0.17 to 0.80; p = 0.012; pheromone primary vs. secondary prevention of sudden cardiac death odds ratio: 0.38; 95% CI: 0.18 to 0.80;

p = 0.011; AF history absence vs. presence odds ratio: 0.27; 95% CI: 0.11 to 0.63; p = 0.003). The rates of all-cause mortality were not statistically different (p = 0.688) between the groups: 21 patients died in the dual-chamber setting group (9.1%) and 18 patients in the single-chamber setting group (8.1%). A breakdown of causes for cardiovascular hospitalization is provided in Table 2. Remarkably, ventricular pacing did not differ significantly between the groups, with a median of 0% in both groups (p = 0.635) and means of 3.9 ± 13.8% in the dual-chamber setting group and 2.4 ± 8.6% in the single-chamber setting group. Atrial pacing in the dual-chamber setting group was on average 26.7 ± 26.3% (median 17.2%). In the total study population, 6 patients (1.