314, 95% confidence interval = 1.033-9.509; p = 0.044).
Conclusion: These results suggest that intensive psychological intervention is necessary for breast cancer patients with large tumors, as well as for women with suspected breast cancer with high HADS scores at pre-consultation. Copyright (C) 2012 John Wiley & Sons, Ltd.”
“Study Design. Retrospective case-control study.
Objective. Determine whether intraoperative cell salvage system use during pediatric posterior spinal fusion (PSF) with segmental spinal instrumentation for idiopathic scoliosis decreases intraoperative C59 solubility dmso and perioperative (intraoperative plus
postoperative) allogeneic blood transfusion.
Summary of Background Data. Intraoperative cell salvage and reinfusion can reduce or obviate perioperative allogeneic blood transfusion. Despite these benefits, their efficacy in pediatric
PSF is unclear. Reported complications include transient hematuria, altered hemostasis, and electrolyte imbalance.
Methods. A total of 54 consecutive idiopathic scoliosis patients were studied: 21 non-cell saver and 33 cell saver patients. Data included age, body mass index, Cobb angle, perioperative hemoglobin levels, ZD1839 in vivo mean arterial pressure, surgical time, levels fused, perioperative estimated blood loss, and perioperative transfusions. A chi(2) and t tests were performed for intraoperative and perioperative allogeneic transfusion between groups. A regression analysis was performed between selected covariates and allogeneic transfusion. Relative risk analysis examined significant covariates regarding allogeneic transfusion rate.
Results. Allogeneic transfusion rates were lower in the cell saver group (6% vs. 55% intraoperative and 18% vs. 55% perioperative, P < 0.05). Mean allogeneic transfusion volumes (mL/kg) were also lower (0.4 vs. 9.1 intraoperative and 1.9 vs. 11.1 perioperative, P < 0.05). Multivariate analysis confirmed these differences
were independent of perioperative blood loss, and also demonstrated that surgical time and blood loss were significantly related to allogeneic transfusion volume. The allogeneic transfusion relative risk was 2.04 in patients with surgery > 6 hours and 5.87 in patients not receiving cell saver blood. All patients with surgeries > 6 hours and estimated blood loss > 30% of total blood volume received cell saver DMH1 chemical structure system blood.
Conclusion. Cell saver use decreased allogeneic transfusion, particularly in surgeries > 6 hours with estimated blood loss > 30% of total blood volume. This study confirms the utility of routine cell saver use during PSF with segmental spinal instrumentation for idiopathic scoliosis.”
“Purpose: Matrix Gla protein (MGP), a potent calcification inhibitor in extracellular matrix, is a molecular determinant regulating vascular calcification. Here, we characterized MGP expression in cultured renal tubular epithelial cells exposed to oxalate and calcium oxalate monohydrate (COM) crystals.