References 1. Bosher JM, Labouesse M: RNA interference: genetic wand and genetic watchdog. Nature Cell Biol 2000, 2:31–36.CrossRef 2. Keene KM, Foy BD, Sanchez-Vargas I, Beaty BJ, Blair CD, Olson KE: RNA interference acts as a natural antiviral response to O’nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles
gambiae . P Natl Acad Sci USA 2004, 101:17240–17245.CrossRef 3. Campbell CL, Keene KM, Brackney DE, Olson KE, Blair CD, Wilusz J, Foy BD: Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC Microbiol 2008, 8:47.PubMedCrossRef 4. Cirimotich CM, Scott JC, Phillips AT, Geiss BJ, Olson KE: Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes. BMC Microbiol 2009, 9:49.PubMedCrossRef 5. Myles KM, Wiley MR, Morazzani selleck find more EM, Adelman ZN: Alphavirus-derived small RNAs
modulate pathogenesis in disease vector mosquitoes. P Natl Acad Sci USA 2008, 105:19938–19943.CrossRef 6. Sanchez-Vargas I, Scott JC, Poole-Smith BK, Franz AWE, Barbosa-Solomieu V, Wilusz J, Olson KE, Blair CD: Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito’s RNA interference pathway. PLOS Pathog 2009, 5:e1000299.PubMedCrossRef 7. Uchil PD, Satchidanandam V: Selleckchem AR-13324 Architecture of the flavivirus replication complex. Protease, nuclease, and detergents reveal encasement within double-layered membrane compartments. J Biol Chem 2003, 278:24388–24398.PubMedCrossRef 8. Medlock JM, Snow KR,
Leach S: Possible ecology and epidemiology of medically important mosquito-borne arboviruses in Great Britain. Epidemiol and Infect 2006, 135:466–482.CrossRef 9. Myles KM, Pierro DJ, Olson KE: Comparison of the transmission potential of two genetically distinct Sindbis viruses after oral infection of Aedes aegypti (Diptera: Culicidae). J Med Entomol 2004, 41:95–106.PubMedCrossRef 10. Taylor RM, Hurlbut HS, Work TH, Kingston JR, Frothingham TE: Sindbis virus: A newly recognized arthropod-transmitted virus. Am J Trop Med Hyg 1955, 4:844–862.PubMed 11. McKnight KL, ifenprodil Simpson DA, Lin S, Knott TA, Polo JM, Pence DF, Johannsen DB, Heidner HW, Davis NL, Johnston RE: Deduced consensus sequence of Sindbis virus strain AR339: Mutations contained in laboratory strains which affect cell culture and in vivo phenotypes. J Virol 1996, 70:1981–1989.PubMed 12. Klimstra WB, Ryman KD, Johnston RE: Adaptation of Sindbis virus to BHK cells selects for use of heparin sulfate as an attachment receptor. J Virol 1998, 72:7357–7366.PubMed 13. Pierro DJ, Powers EL, Olson KE: Genetic determinants of Sindbis virus strain TR339 affecting midgut infection in the mosquito Aedes aegypti . J Gen Virol 2007, 88:1545–1554.PubMedCrossRef 14. Hardy JL, Houk EJ, Kramer LD, Reeves WC: Intrinsic factors affecting vector competence of mosquitoes for arboviruses. Annu Rev Entomol 1983, 28:229–262.PubMedCrossRef 15.