Results: A total of 333 patients were included, 171 (51.4%) with and 162 (48.6%) without PPIs. The PPIs-users were significantly older in age (p = 0.001). There were not statistical difference between the two groups in sex distribution and etiology of cirrhosis (p > 0.05 for both parameters). The PPIs-users had a significantly higher incidence of overall bacterial infection rate (25.7%) than non-PPIs-users (13.5%), p = 0.005. On the multivariate analysis, older age >60 years, (OR = 1.246, 95% CI 1.021-08.486; p = 0.02), and PPIs-use (OR = 2.149, 95% CI 1.124-06.188;

p = 0.01) were independent predicting factors for overall bacterial infection. The indication for PPIs use was undocumented in 43% of patients. Staurosporine in vitro Conclusion: The present study shows that PPIs use, as well as older age >60 years, was an independent predicting factor for the development of bacterial infection in hospitalized cirrhotic patients. Unless it is indicated, PPI therapy should be avoided in this group of patients, in particular those with older than 60 years of age. Key Word(s): 1. cirrhosis; 2. infection; 3. PPI Presenting Author: FANDY GOSAL Additional Authors: BJ WALELENG, K PANDELAKI Corresponding Author: FANDY GOSAL Affiliations: University of Sam Ratulangi, University of Sam Ratulangi Objective: To date, non-alcoholic fatty liver remains one of the public health problems, not only

in adults but also in children and adolescents. Obesity is a risk factor that is closely related to non-alcoholic fatty liver. Insulin resistance occurs in obesity leading to lypolisis, followed by an increase in free fatty Saracatinib acids and synthesis of triglycerides with the final outcome of a fatty liver development. TNF-alpha as a pro-inflammatory cytokine plays a role in fatty liver pathogenesis 上海皓元 in which TNF-alpha levels may induce the development of insulin resistance. Methods: To investigate the association

of TNF-alpha and HOMA-IR values with simple non-alcoholic fatty liver in senior high school students with obesity. Results: This was an observational analytic with cross sectional study. This study was conducted in Prof.dr.R.D.Kandou Manado General Hospital starting from July 2012 to September 2012. Conclusion: Based on statistical analysis for association between TNF-alpha and HOMA-IR, this study found the contingency coefficient was 0.16 and the odd ratio (OR) was 3.37 with confidential interval (CI) 0.24–46.35. While based on statistical analysis for association between TNF-alpha and fatty liver, it was found that the contingency coefficient was 0.05 and the OR was 1.40 with CI 0.20–9.66. This study also found a contingency coefficient of 0.28 with CI 0.246–46.362 based on statistical analysis for association between HOMA-IR values and fatty liver. Key Word(s): 1. TNF-alpha; 2. HOMA-IR; 3. non-alcoholic fatty liver; 4.