5%). This was a deliberately open ended question Protease Inhibitor Library research buy and the reason most respondents opted for this preference was that they felt this would allow them to remember to refill the reservoir on a set time every week. The bottom-up survey was designed to gain an understanding of insulin pump therapy together with users’

experiences of their condition and treating it with infused insulin. This was aimed at gauging their opinions of whether a closed loop implantable insulin pump was an attractive proposition, the premise being that, since they already manage their diabetes in a partly automated way, they might be particularly perceptive about the prospect in ways not obvious to others. Many of the background responses implied that pump users were all type 1 and that they had been diagnosed early in life. The majority of the respondents were from the UK and North America. The lack of responses from France may have been as a result of the survey being written in English, as Sulmont et al.16

have reported that insulin pump use in France, especially for children and adolescents with T1DM, increased 10-fold between 2001 and 2007. A higher proportion of patients with T1DM in the USA use pumps compared with UK residents and these are funded by the medical insurance companies. In the UK, the criteria for pump use are somewhat different and depend more on the local commissioners implementing NICE guidelines17 for pump use. Clear choices emerged for the pump brand and the insulin type. Bartalo et al.18 have shown that there are no pharmacokinetic or pharmacodynamic differences in the absorption profiles of insulin lispro and aspart and conclude that the use of Selleck Pritelivir short-acting insulin in CSII therapy provides a small but statistically significant improvement in glycaemic control compared with regular insulin. Glycaemic control was also dependent on the infusion line and has been shown to deteriorate after 48 hours of use leading to an incremental loss of glycaemic control.19 In this survey,

quantities of insulin used per day and the dose rate used were variable but within expected ranges. In general terms, pump users are reported to need about 80% of the dose given to T1DM people by injection, and Methane monooxygenase this relates to the efficiency of converting long-acting insulins to diffusible insulin that can reach the plasma. Basal insulin needs were found to be <1 unit/hr for most of the respondents. Insulin requirements are believed to increase during the night and early morning (dawn phenomenon) due to a decrease in insulin sensitivity caused by cortisol and growth hormone secretion. Basal insulin requirement begins peaking in juveniles (<20 years) before midnight and maintains a relative high throughout the night,20 drops in the morning and increases again from noon to midnight. Basal needs for adults (>20 years) show a more abrupt peak in the morning followed by a drop off until noon and gradually increasing in the evening.