for C21H25N3O4: C, 65.78; H, 6.57; N, 10.96; O, 16.69. Found: C, 65.91; H, 6.35; N, 11.07. Yellow gummy solid, 1H NMR (400 MHz, CDCl3): δ 2.33 (s, 3H), 2.68 (brs, 4H), 3.04 (brs, 4H), 3.66 (s, 2H), 3.77 (s, 3H) 3.88 (s, 3H), 6.91–6.93 (m, 1H), 7.09–7.14 (m, 2H), 8.21 (s, 1H). 13C NMR (100 MHz, CDCl3): δ (ppm) 164.02, 156.19, 151.42, 148.6, 133.94, 127.43, 127.35, 126.09, 125.00, Dabrafenib mw 124.34, 118.54, 62.68, 59.83, 53.32, 51.30, 13.24, 11.00; MS (e/z): 379,
381 (M−, M+). Anal. calcd. for C19H23Cl2N3O: C, 60.00; H, 6.10; Cl, 18.64; N, 11.05; O, 4.21. Found: C, 60.11; H, 6.05; N, 11.15. Pale yellow gummy solid, Mass (e/z): 1H NMR (400 MHz, CDCl3): δ 2.06–2.27 (m, 2H), 2.27 (s, 3H), 2.69 (brs, 4H), 3.05 (brs, 4H), 3.36 (s, 3H), 3.58 (m, 2H), BEZ235 datasheet 4.10 (t, 3H), 6.69 (d J = 5.6 Hz, 2H), 6.91–6.93 (m, 1H), 7.09–7.14 (m, 2H), 8.30 (s, 1H). 13C NMR (100 MHz, CDCl3): δ (ppm) 163.01, 157.09, 151.82, 149.6, 134.25, 128.42, 127.43, 126.28, 125.12, 124.45, 118.65, 77.53, 71.42, 64.51, 62.82, 59.94, 53.45, 51.41, 11.28; MS (e/z): 423, 425 (M−, M+). Anal. calcd. for C21H27Cl2N3O2: C, 59.44; H, 6.41; Cl, 16.71; N, 9.90; O, 7.54. Found: C, 59.56; H, 6.34; N, 9.98. Light brown colour syrup. 1H NMR (400 MHz, CDCl3): δ 2.32 (s, 3H), 2.69 (brs, 4H), 3.05 (brs, 4H), 3.73 (s, 2H), 4.36–4.4.42 (q = 3H), 6.64 (d, J = 8 Hz, 1H), 6.91–6.93 (m, 1H), 7.01–7.05 (m, 4H), 8.36 (d, J = 5.6 Hz, 1H). 13C NMR (100 MHz, CDCl3): δ (ppm) 163.13, 157.18,
151.91, 149.62, 134.31, 128.52, 127.32, 126.34, 125.21, 124.52, 122.12, 118.72, 85.72, 62.99, 60.08, 53.65, 51.61, 11.45; Mass (e/z): 433, 435 (M−, M+). Anal. calcd. for C19H20Cl2F3N3O: C, 52.55; H, 4.64; Cl, 16.33; F, 13.12; N, 9.68; O, 3.68. Found: C, 52.66; H, 4.57; N, 9.78. Pale yellow colour syrup. 1H NMR (400 MHz, CDCl3): δ 2.76 (brs, 4H), 3.07 (brs, 4H), 3.77 (s, 2H), 3.77 (s, 3H) 3.88 (s, 3H), 6.81 (d, J = 7.6 Hz, Unoprostone 1H), 6.92–6.94 (m, 1H), 7.01–7.14 (m, 2H), 8.27 (d, J = 5.6 Hz, 1H). ); 13C NMR (100 MHz, CDCl3): δ (ppm) 158.6, 151.3, 145.6, 127.4, 124.3, 118.5, 106.7, 77.5, 77.17, 76.8, 61.08, 58.12, 55.61, 53.27, 51.13; MS (e/z): 381, 383 (M−, M+).