“Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital heart defect. ALCAPA is asymptomatic in many cases in newborn periode. It is mostly diagnosed in the first few months. In this case report, we present a newborn with ALCAPA who admitted to our clinic with heart failure occurred at an earlier age than expected. The electrocardiography showed deep wide Q waves in D1 and aVL, ST elevation in leads
V1-V6. Echocardiography revealed a dilated cardiomyopathy and left main coronary artery originates from pulmonary artery. Diagnosis was confirmed by coronary angiography. In this report, we emphasized that ALCAPA may cause dilated cardiomyopathy also in newborn period and ACY-738 we aimed that enhanced awareness of this disease. (Turk Arch Ped 2011; 46:256-8)”
“Purpose. The pharmacology, pharmacodynamics, pharmacokinetics, safety, efficacy, find more and place in therapy of alogliptin and its combinations for managing type 2 diabetes mellitus are reviewed. Summary. Alogliptin is a selective, orally bioavailable inhibitor of the enzymatic activity of dipeptidyl peptidase-4 (DPP-4). It works by slowing the inactivation of the incretin hormones, thereby increasing their concentrations in the bloodstream and reducing fasting and postprandial glucose concentrations in a glucose-dependent
manner in patients with type 2 diabetes mellitus. Alogliptin has a moderate degree of absorption, estimated to exceed 75%, and its absorption is not affected by food.
No drug interactions are known to be associated with alogliptin monotherapy. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. The clinical efficacy and safety of alogliptin have been demonstrated in several clinical trials, reducing patients’ glycosylated buy Compound Library hemoglobin level by 0.4-1.0% in 26 weeks. Alogliptin does not require any dosage adjustment when coadministered with ketoconazole, fluconazole, gemfibrozil, warfarin, metformin, glyburide, and pioglitazone. Alogliptin selectively binds to and inhibits DPP-4 in vitro at concentrations approximating therapeutic exposures. The most common adverse events associated with alogliptin are nasopharyngitis, headache, and upper respiratory tract infection. As with the other DPP-4 inhibitors, use of alogliptin may be associated with the development of pancreatitis during therapy. Conclusion. Alogliptin, a selective DPP-4 inhibitor, does not differ greatly from the other DPP-4 inhibitors currently available. It can be used as monotherapy or in combination with metformin for the management of type 2 diabetes.”
“Motivation: The urgent need for efficient and sustainable biological production of fuels and high-value chemicals has elicited a wave of in silico techniques for identifying promising novel pathways to these compounds in large putative metabolic networks.